1 film-coated tablet contains 1000 mg of micronised diosmin (Diosminum).
Symptoms of chronic venous insufficiency of the lower extremities:
- aching or cramping of the legs
- feeling of heavy legs
- varicose veins of the lower extremities
- dilated capillaries, so called spider veins
- swollen legs
Symptomatic treatment of haemorrhoids.
Mode of Action
Diosmin influences microcirculation and haemorheological parameters of the circulation. Diosmin protects venous blood vessels (twice as strong as troxerutin ), reduces their permeability, improves blood vessel wall flexibility and tone (e.g. as a result of prolonged contraction of blood vessel muscle fibres in response to noradrenaline and increased myocyte calcium sensitivity).
Diosmin helps blood to return from the legs to the heart, thus lowering blood pressure and reduces venous stasis. It acts as an inhibitor of pathologic leukocyte activation and adhesion to the capillaries and lowers blood viscosity. By blocking the production of mediators involved in the inflammatory reaction (it inhibits the synthesis of prostaglandins, has an antioxidative effect, inhibits formation of free radicals, interferes with histamine release, inhibits hyaluronidase and ceruloplasmin activity), it exhibits anti-inflammatory properties. Diosmin acts on the lymphatic system by increasing lymph flow and lymph oncotic pressure. Like other flavonoids, disomin is found to be a strong inhibitor of prostaglandin E2, F2α and thromboxane (A2 and/or B2), by blocking leukocyte activation, migration, and adhesion, as well as activation of neutrophils.
Instructions for use:
Take 1 coated tablet daily with a meal. Only in more severe cases of haemorrhoids, higher doses of the medication can be used on a short-term basis: 1 coated tablet 3 times daily for 4 days, to be followed by 1 tablet twice daily for another 3 days in the morning and in the evening.